Saath Nibhaana Saathiya 2

• Sneha Jain as Gehna Seth: Kusum's daughter; Swara's sister; Anant's widow; Surya's wife (2020–present)
• Gautam Vig as Surya Seth: Suhani's son: Kabir and Sarika's brother; Gehna's second husband (2022–present)

• Harsh Nagar as Anant Desai: Gehna’s first husband; Jamuna and Prafu’s youngest son; Hiral, Chetan, Tia and Pankaj’s younger brother (2020-2022) (Dead)
• Akanksha Juneja as Kanak Desai: Jigna's daughter; Pankaj's wife; Gehna's rival (2020–present)
• Roma Bali as Suhani Seth: Late Mahendra's wife; Surya, Sarika and Kabir's mother (2022–present)
• Aliraza Namdar as Praful Desai: Revati's elder son; Paresh, Kokila and Jigna's brother; Jamuna's husband; Pankaj, Hiral, Chetan, Anant and Tia's father; Piyush, Saachi and Tannu's grandfather (2020–present)
• Anuradha Kanabar Namdar as Jamuna Narang Desai: Rasika and Hansa's sister; Praful's wife; Pankaj, Hiral, Chetan, Anant and Tia's mother; Piyush, Saachi and Tannu's grandmother (2020–present)
• Hitesh Dave as Paresh Desai: Revati's younger son; Praful, Kokila and Jigna's brother (2021–present)
• Nadia Himani as Hema Majethia Desai: Bhavani and Dashrath's daughter; Sagar's sister; Chetan's wife; Piyush and Saachi's mother (2020–present)
• Prakash V. Wagela as Chetan Desai: Jamuna and Praful's second son; Pankaj, Hiral, Anant and Tia's brother; Hema's husband; Piyush and Saachi's father (2020–present)
• Jay Pathak as Pankaj Desai: Jamuna and Praful's eldest son; Hiral, Chetan, Anant and Tia's brother; Kanak and Swara's husband (2020–present)
• Manas Adhiya as Sagar Majethia: Bhavani and Dashrath's son; Hema's brother; Suman's husband; Kanak's accomplice (2020–present)
• Hardika Joshi as Hiral Desai Parekh: Jamuna and Praful's elder daughter; Pankaj, Chetan, Anant and Tia's sister; Sapan's wife; Tannu's mother (2020–present)
• Ankur Panchal as Sapan Parekh: Hiral's husband; Tannu's father (2020–present)
• Jinal Jain as Tia Desai: Jamuna and Praful's younger daughter; Pankaj, Hiral, Chetan and Anant's sister; Krishna's fiancé (2020–present)
• Sanket Choukse as Krishna Rawat: Gehna's childhood friend; Tia's fiancé (2021–present)
• Sujata Agarwal as Rasika Narang: Jamuna and Hansa's sister (2021–2022)
• Ashar Khan as Piyush Desai: Hema and Chetan's son; Saachi's brother (2020–2021)
• Aarifa Siddiqui as Saachi Desai: Hema and Chetan's daughter; Piyush's sister (2020–2021)
• Prachi Bisht as Tanushree "Tanu" Parekh: Hiral and Sapan's daughter (2020-2021)
• Krutika Desai as Radhika Virani: Anant's ex fiancé; Vineet's ex-wife (2020–2021)
• Sachin Parikh as Vineet Virani: Radhika's ex-husband (2021)
• Khyati Vaghela as Mayuri Tripathi: Samarth's wife (2021)
• Leela Tejwani as Hansa Narang Tripathi: Rasika and Jamuna's sister; Samarth's mother (2021)
• Himanshu Gokani as Dashrath Majethia: Bhavani's husband; Hema and Sagar's father; Kanak's accomplice (2021)
• Durga Mahlotra as Bhavani Majethia: Dashrath's wife; Hema and Sagar's mother (2021)
• Mohini Singh as Suman Majethia: Sagar's wife (2021)
• Subhalaxmi Das as Jigna Dholakia: Kanak's mother and accomplice (2021)
• Deepika Agarwal as Mona Verma: Kanak's fashion expert (2021)
• Sudhir Jain as Amrish Mehta: An arrogant model advisor (2021)
• Riya Mehta as Shivangi Mehta: A model advisor (2021)
• Sikandar Kharbanda as Professor Satyansh Kumar: Sagar's boss (2021)
• Anshul Bamni as Dr. Srivastava: Senior Officer of Anant's secret mission; Sia's brother (2021)
• Pratibha Tiwari as Sia Srivastava: Srivastava's sister (2021)
• Rashmi Gupta as Swara Patel Desai: Kusum's younger daughter; Gehna's sister; Pankaj's second wife (2021-present)
• Vaishali Thakkar as Kusum Patel: Swara and Gehna's mother (2021)
• Faizal Sayed as Dr. Abhay Sinha: Shanti's fake son; Priya's fake brother; Kajal's widower; Gehna's obsessed lover (2021-present)
• Ishan Jain as Rohan Sinha: Abhay's fake son; Kajal's son (2022)
• Urvi Gor as Priya Sinha: Shanti's fake daughter; Abhay's fake sister; Rohan's fake aunt (2022)
• Chetna Joshi as Shanti Sinha: Abhay and Priya's fake mother; Rohan's fake grandmother (2022)
• Rajesh Puri as Rajesh Seth; Kabir, Sarika and Surya's grandfather (2022–Present)
• Hargun Grover as Kabir Seth: Suhani's son; Surya and Sarika's elder brother (2022–Present)
• Ashish Drall as Arjun: Sarika's husband; Suhani's son-in-law (2022–Present)
• Pratibha Goregaonkar as Dimple Rajesh Seth: Kabir, Sarika and Surya's grandmother; Rajesh's wife. Suhani's Mother-in-law (2022–Present)
• Swati Bakshi as Sarika Seth: Arjun's wife. Suhani's daughter; Surya and Kabir's sister (2022–Present)
• Namrata Tiwari as Shreya Kabir Seth: Kabir's wife; Suhani's daughter-in-law (2022-present)
• Kashish Duggal Paul
• Baby Farida

The original cast from season one were seen in a span of beginning episodes during October to November 2020, to introduce the main characters.[5][6]

• Devoleena Bhattacharjee as Gopi Kapadia Modi: Jayantilal and Madhu's elder daughter; Radha's sister; Rashi's cousin; Ahem and Jaggi's wife; Meera,Vidya and Ramakant's mother; (2020)
• Rupal Patel as Kokila Desai Modi: Revati's elder daughter; Praful, Paresh and Jigna's sister; Parag's wife; Ahem and Kinjal's mother; Jaggi's step-mother; Meera, Vidya and Ramakant's grandmother. She is the strict and dominating matriarch of the Modi family (2020)
• Mohammad Nazim as
  • Ahem Modi: Parag and Kokila's son; Kinjal's brother; Jaggi's half-brother; Gopi's first husband; Meera, Vidya and Ramakant's father; . He was assumed dead but he survived and only lost his memory as Gehna saved and took care of him. Later, he regains his memory and unites with his family (2020)
  • Jaggi Modi: Urvashi and Parag's son; Kokila's step-son; Ahem and Kinjal's half-brother; Gopi's second husband; Meera, Vidya and Ramakant's uncle and step-father. He married her after Ahem's supposed demise (2020)
• Manish Arora as Parag Modi: Janko and Tolaram's younger son; Chirag's brother; Kokila's husband; Ahem, Jaggi and Kinjal's father; Meera, Vidya and Ramakant's grandfather. (2020)
• Swati Shah as Hetal Modi: Chirag's wife; Kokila's cousin turned elder sister-in-law,Jigar's mother. She is sweet and sensible, and always thinks about the welfare of Modi's (2020)
• Vandana Vithlani as Urmila Shah: Jitu's wife; Rashi's mother,Gopi's aunt(2020)

In July 2020, Devoleena Bhattacharjee signed the contract for the new season with the production under plans since a year before.[7][8] Admist this, the rap by Yashraj Mukhate released on 21 August 2020 went viral and the re-run of the series Saath Nibhaana Saathiya during the Coronavirus lockdown was garnering good ratings which made the makers to immediately start production of the new season of the series and released the first promo on 31 August 2020 featuring Bhattacharjee reprising her role of Gopi Modi while the casting was not even started.[9]

Based on the backdrop of Surat, in Gujarat, the series is completely filmed at the Ramdev Studio in Naigaon.[10]

On 14 April 2021, shooting halted due to COVID-19 precautions set by Uddhav Thackeray, the chief minister of Maharashtra. On 18 and 19 April, the entire team of Saath Nibhaana Saathiya 2 shifted their base to Agra and continued shooting there till early June.[11]

The series premiered on 19 October 2020 at 9.00 pm time slot on StarPlus.[12]

With the release of first promo, Devoleena Bhattacharjee, Rupal Patel and Mohammad Nazim were confirmed reprising their roles of Gopi, Kokila and Ahem Modi/Jaggi Modi (double role).[13][14][15] Vishal Singh confirmed being approached for reprising their role of Jigar Modi, but finally declined it.[16] Rucha Hasabnis declined to reprise her role as Rashi Modi in the new season, as her character had died in the former season and that she did not wish to perform a role in a typical family drama.[17]

On 13 September 2020, Sneha Jain and Harsh Nagar were confirmed to reprise their lead roles as Gehna and Anant.[18] Soon, with the first look of the series, Vandana Vittlanee, Swati Shah and Manish Arora were confirmed reprising their roles of Urmila Shah, Hetal Modi and Parag Modi from the former season.[5] Besides the former season's cast and the leads, Jay Pathak, Akanksha Juneja, Nadia Himani, Prakash Vaghela, Aliraza Namdar and Anuradha Kanabar were cast to perform the recurring roles of the show.

Soon, it was revealed that the cast from the first season were only shooting for a few episodes in order to introduce the new leads of the show. In mid-November 2020, the entire cast of the former season quit the series due to the promoter's demand on having only one track and that the show completely focused on the original show, Ke Apon Ke Por.[6]

In June 2021, lead actress, Akanksha Juneja took a break from the sets. During her absence, the show focused on Hema Desai aka Nadia Himani. The show also changed the storyline slightly due to Juneja's absence and introduced a new character, Krishna, played by Sanket Chouske.[19]

The Times of India reviewed, "Ahem's mysterious presence in Gopi's life, Kokila's sass and injustice towards Gehna will keep you hooked."[20] India Today criticized the launch of the new season as unnecessary and on the other hand criticizing the former season saying, "During the course of seven years, the show took three major leaps – eight years, 10 years and four years. That is 22 years in total. Yet they've something left to tell the audience? Needless to say, how the show turned to be ridiculous on several occasions. Saath Nibhaana Saathiya tried to be progressive but the show was regressive to the core."[21][22][23]