SIDT1

SIDT1
Identifiers
Aliases	SIDT1, B830021E24Rik, SID-1, SID1, SID1 transmembrane family member 1
External IDs	OMIM: 606816 MGI: 2443155 HomoloGene: 41189 GeneCards: SIDT1
Gene location (Human)
Chr.	Chromosome 3 (human)[1]
End	113,629,575 bp[1]
Gene location (Mouse)
Chr.	Chromosome 16 (mouse)[2]
End	44,153,559 bp[2]
RNA expression pattern
	Top expressed in
	cerebellar hemisphere; ; cerebellar vermis; ; colon; ; rectum; ; blood; ; stomach;
	More reference expression data
	n/a
Gene ontology
Molecular function	RNA transmembrane transporter activity; RNA binding; double-stranded RNA binding;
Cellular component	membrane; integral component of membrane; lysosome; plasma membrane;
Biological process	dsRNA transport; RNA transport;
	Sources:Amigo / QuickGO
Orthologs
	54847
	320007
	ENSG00000072858
	ENSMUSG00000022696
	Q9NXL6
	Q6AXF6
NM_001308350; NM_017699; NM_001322294; NM_001322295; NM_001322296;
	NM_001322297; NM_001322298; NM_001322299; NM_001322300
	NM_001159419; NM_198034
NP_001295279; NP_001309223; NP_001309224; NP_001309225; NP_001309226;
	NP_001309227; NP_001309228; NP_001309229; NP_060169
	NP_001152891; NP_932151
	Wikidata
View/Edit Human	View/Edit Mouse

SID1 transmembrane family member 1 is a protein that in humans is encoded by the SIDT1 gene. [5]

Function

The protein encoded by this gene belongs to SID1 family of transmembrane dsRNA-gated channels. Family members transport dsRNA into cells and are required for systemic RNA interference.

References

GRCh38: Ensembl release 89: ENSG00000072858 - Ensembl, May 2017
GRCm38: Ensembl release 89: ENSMUSG00000022696 - Ensembl, May 2017
"Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
"Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
"Entrez Gene: SID1 transmembrane family member 1". Retrieved 2017-10-02.

Rose JE, Behm FM, Drgon T, Johnson C, Uhl GR (2010). "Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score". Mol. Med. 16 (7–8): 247–53. doi:10.2119/molmed.2009.00159. PMC 2896464. PMID 20379614.
Elhassan MO, Christie J, Duxbury MS (2012). "Homo sapiens systemic RNA interference-defective-1 transmembrane family member 1 (SIDT1) protein mediates contact-dependent small RNA transfer and microRNA-21-driven chemoresistance". J. Biol. Chem. 287 (8): 5267–77. doi:10.1074/jbc.M111.318865. PMC 3285307. PMID 22174421.

This article incorporates text from the United States National Library of Medicine, which is in the public domain.

This article is issued from Wikipedia. The text is licensed under Creative Commons - Attribution - Sharealike. Additional terms may apply for the media files.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000072858 - Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000022696 - Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[entrez-5] "Entrez Gene: SID1 transmembrane family member 1". Retrieved 2017-10-02.

SIDT1

Function

References

Further reading