List of human spaceflights, 2021–present

This is a detailed list of human spaceflights from 2021 to present.

• Green indicates a suborbital flight (including flights that failed to attain intended orbit).

#	Crew	Launch spacecraft	Habitation		Return spacecraft	Brief mission summary
329	Oleg Novitsky (3)	9 April 2021 Soyuz MS-18	ISS (crew 64/65)		17 October 2021 Soyuz MS-18	ISS crew rotation.
	Pyotr Dubrov Mark T. Vande Hei (2)		ISS (crew 64/65/66)		30 March 2022 Soyuz MS-19
330	Shane Kimbrough (3) K. Megan McArthur (2) Akihiko Hoshide (3) Thomas Pesquet (2)	23 April 2021 SpaceX Crew-2, Endeavour	ISS (crew 65/66)		9 November 2021 SpaceX Crew-2, Endeavour	ISS crew rotation.
—	Frederick W. Sturckow Dave Mackay	22 May 2021 Unity 21				First human spaceflight from the State of New Mexico. Reached an altitude of 89.24 km (55.45 mi), crossing the U.S. definition of space, but not the FAI's definition.
331	Nie Haisheng (3) Liu Boming (2) Tang Hongbo	17 June 2021 Shenzhou 12	TSS		17 September 2021 Shenzhou 12	First crew to Tiangong Space Station.
—	David Mackay Michael Masucci Beth Moses Richard Branson Colin Bennett Sirisha Bandla	11 July 2021 Unity 22				Reached an altitude of 86 km (53 mi), crossing the U.S. definition of space.
332	Jeff Bezos Mark Bezos Wally Funk Oliver Daemen	20 July 2021 NS 16				Reached an altitude of 107 km (66 mi), crossing the FAI definition of space.
333	Jared Isaacman Sian Proctor Hayley Arceneaux Christopher Sembroski	16 September 2021 Inspiration4, Resilience		18 September 2021 Inspiration4, Resilience
334	Klim Shipenko Yulia Peresild	5 October 2021 Soyuz MS-19	ISS (Vyzov)		17 October 2021 Soyuz MS-18	ISS crew rotation.
	Anton Shkaplerov (4)		ISS (crew 65/66)		30 March 2022 Soyuz MS-19
335	Audrey Powers Chris Boshuizen Glen de Vries William Shatner	13 October 2021 NS 18				Reached an altitude of 107 km (66 mi), crossing the FAI definition of space.
336	Zhai Zhigang (2) Wang Yaping (2) Ye Guangfu	15 October 2021 Shenzhou 13	TSS		16 April 2022 Shenzhou 13	Second crew to Tiangong Space Station.
337	Raja Chari Thomas Marshburn (3) Kayla Barron Matthias Maurer	11 November 2021 SpaceX Crew-3, Endurance	ISS (crew 66/67)		in orbit	ISS crew rotation.
338	Alexander Misurkin (3) Yusaku Maezawa Yozo Hirano	8 December 2021, Soyuz MS-20	ISS		20 December 2021, Soyuz MS-20
339	Laura Shepard Churchley Michael Strahan Dylan Taylor Evan Dick Lane Bess Cameron Bess	11 December 2021 NS 19				Reached an altitude of greater than 100 km (62 mi), crossing the FAI definition of space.
340	Oleg Artemyev (3) Denis Matveev Sergey Korsakov	18 March 2022, Soyuz MS-21	ISS (crew 66/67)		in orbit	ISS crew rotation.
341	Marty Allen Sharon Hagle Marc Hagle Jim Kitchen George Nield Gary Lai	31 March 2022 NS 20				Reached an altitude of greater than 100 km (62 mi), crossing the FAI definition of space.
342	/ Michael López-Alegría (5) Larry Connor Mark Pathy Eytan Stibbe	8 April 2022, Axiom Mission 1, Endeavour	ISS		25 April 2022, Axiom Mission 1, Endeavour
343	Kjell N. Lindgren (2) Robert Hines Samantha Cristoforetti (2) Jessica Watkins	27 April 2022 SpaceX Crew-4, Freedom	ISS (crew 67/68)		in orbit	ISS crew rotation.