Kristen Kroll

Kristen Kroll is an American developmental biologist, and is the Professor of Developmental Biology at Washington University School of Medicine since 2021.

Kristen L Kroll
Alma mater
Known forTranscriptional and epigenetic regulation of brain development
Scientific career
FieldsDevelopmental Biology, Neuroscience, Transcription, Epigenetics
InstitutionsWashington University School of Medicine

Early life and education

In 1988, Kroll received her Bachelor of Arts degree with the highest honors in Molecular and Cell Biology from Northwestern University[1] and earned her Ph.D. in 1994 from the University of California, Berkeley.[2]

Career and research

During her pre-doctoral training, she worked in the laboratory of John C. Gerhart' in Kroll's thesis research, she introduced a nuclear transplantation-based approach for transgenesis in embryos of Xenopus laevis. Together with Dr. Enrique Amaya, they developed an approach for making transgenic embryos that involved combining sperm nuclei, DNA, and interphase cell extract in a tube[3][4][5] in which without breeding they used nuclear transfer-based transgenesis to produce animals with stable transgene integration in each cell. The development of this approach expanded the utility of Xenopus laevis for studying vertebrate embryogenesis.[6]

After earning her Ph.D. from Berkeley, she did postdoctoral research at Harvard Medical School. Her postdoctoral fellowship was supervised by Marc Kirschner from 1994 to 2000, in which she used functional screening of cDNA libraries to define novel regulators of early embryonic development. These included the nuclear protein Geminin (Gmnn), a novel protein that was identified based upon its ability to expand the Xenopus laevis neural plate at the expense of non-neural tissue.[7][3]

Faculty career

From 1998 to 2000, she worked as an independent consultant at Genetics Institute in Cambridge, Massachusetts.[2] In 2000, Kroll was appointed assistant professor at Washington University School of Medicine, Department of Molecular Biology and Pharmacology. In 2007, she was appointed Associate Professor at Washington University School of Medicine, Department of Developmental Biology, and was appointed Professor of Developmental Biology at Washington University School of Medicine in 2021.[2]

Accolades

Kroll has received several awards for her work, including the March of Dimes Basil O’Connor Award, the American Cancer Society Research Scholar grant, and American Cancer Society Hope Award.[8]

Selected publications

Kristen Kroll has more than 50 publications in the field of developmental biology including:

  • Kroll, K.L.; Amaya, E. (1996-10-01). "Transgenic Xenopus embryos from sperm nuclear transplantations reveal FGF signaling requirements during gastrulation". Development. The Company of Biologists. 122 (10): 3173–3183. doi:10.1242/dev.122.10.3173. ISSN 1477-9129. PMID 8898230.
  • Postigo, A. A. (2003-05-15). "Regulation of Smad signaling through a differential recruitment of coactivators and corepressors by ZEB proteins". The EMBO Journal. Wiley. 22 (10): 2453–2462. doi:10.1093/emboj/cdg226. ISSN 1460-2075. PMC 155984. PMID 12743039.

References
  1. "Wilmot Union High School - Alumni Hall of Fame". www.wilmothighschool.com. Retrieved 2022-03-24.
  2. "Kristen Kroll". Kroll Lab. 2019-04-26. Retrieved 2022-03-24.
  3. "Kristen Kroll, Breaking New Ground in Understanding Brain Development".
  4. Kroll, K.L.; Amaya, E. (1996-10-01). "Transgenic Xenopus embryos from sperm nuclear transplantations reveal FGF signaling requirements during gastrulation". Development. 122 (10): 3173–3183. doi:10.1242/dev.122.10.3173. ISSN 1477-9129. PMID 8898230.
  5. Kroll, Kristen L.; Gerhart, John C. (1994-10-28). "Transgenic X. laevis Embryos from Eggs Transplanted with Nuclei of Transfected Cultured Cells". Science. 266 (5185): 650–653. Bibcode:1994Sci...266..650K. doi:10.1126/science.7939720. ISSN 0036-8075. PMID 7939720.
  6. Amaya, Enrique; Kroll, Kristen (2010-08-21). "Production of Transgenic Xenopus laevis by Restriction Enzyme Mediated Integration and Nuclear Transplantation". Journal of Visualized Experiments (42): 2010. doi:10.3791/2010. ISSN 1940-087X. PMC 3156005. PMID 20811326.
  7. Kroll, K. L.; Salic, A. N.; Evans, L. M.; Kirschner, M. W. (1998). "Geminin, a neuralizing molecule that demarcates the future neural plate at the onset of gastrulation". Development (Cambridge, England). 125 (16): 3247–3258. doi:10.1242/dev.125.16.3247. ISSN 0950-1991. PMID 9671596.
  8. "Kristen L. Kroll - Washington University School of Medicine". Open Access Government. Retrieved 2022-03-24.
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