Virginia L. Miller

Virginia L. Miller is a microbiologist known for her work studying the factors leading to disease caused by bacteria. Miller is an elected fellow of the American Academy of Microbiology (2003) and a former Pew Charitable Trust Biomedical Scholar (1989).[1]

Virginia Miller
Alma mater
Scientific career
Institutions
ThesisAnalysis of the cholera toxin positive regulatory gene, toxR (1985)

Education and career

Miller has a B.A. from the University of California, Santa Barbara (1979).[2] She earned her Ph.D. from Harvard University in 1985 where she worked on the expression of genes associated with Cholera toxin.[3] Following her Ph.D., she was a postdoc at Stanford University.[4] She moved to the University of California, Los Angeles in 1988 and earned tenure in 1994.[5] She moved to Washington University in St. Louis in 1996, and then to the University of North Carolina at Chapel Hill in 2008.[4] As of 2021, Miller is a professor of genetics, microbiology, and immunology at the University of North Carolina at Chapel Hill.[2]

Research

Miller is known for her research into bacterial pathogenesis, the factors leading to the onset of disease from specific species of bacteria. Her early research examined the synthesis of the cholera toxin by Vibrio cholerae[6][7] and identified environmental signals that lead V. cholerae to express the proteins needed to make the cholera toxin.[8] She went on to examine the mechanisms by which another bacteria pathogen - Yersinia pestis - enters cells[9] and cause disease.[10] She has also worked on how Salmonella[11][12] and Klebsiella pneumoniae[13][14] cause disease.

Awards and honors

In 1989, Miller was named a Pew Scholar.[15] In 2003, Miller was elected a fellow of the American Academy of Microbiology.[16][5]

Selected publications

References
  1. "Virginia L. Miller, PhD". PEW Trusts - Biomedical Scholars (1989). Retrieved 2022-03-16.
  2. "Virginia Miller, PhD". Institute for Global Health and Infectious Diseases. Retrieved 2021-12-04.
  3. Miller, Virginia L (1985). Analysis of the cholera toxin positive regulatory gene, toxR (Thesis). OCLC 17572198.
  4. "Virginia Miller, Ph.D." ASM.org. Retrieved 2021-11-30.
  5. "Miller biographical sketch" (PDF). 2014-02-23. Archived (PDF) from the original on 2014-02-23. Retrieved 2021-12-04.
  6. Miller, V. L.; Mekalanos, J. J. (1984-06-01). "Synthesis of cholera toxin is positively regulated at the transcriptional level by toxR". Proceedings of the National Academy of Sciences. 81 (11): 3471–3475. Bibcode:1984PNAS...81.3471M. doi:10.1073/pnas.81.11.3471. ISSN 0027-8424. PMC 345530. PMID 6374658.
  7. Miller, Virginia L.; Taylor, Ronald K.; Mekalanos, John J. (1987). "Cholera toxin transcriptional activator ToxR is a transmembrane DNA binding protein". Cell. 48 (2): 271–279. doi:10.1016/0092-8674(87)90430-2. PMID 3802195. S2CID 28576010.
  8. Miller, V L; Mekalanos, J J (1988-06-01). "A novel suicide vector and its use in construction of insertion mutations: osmoregulation of outer membrane proteins and virulence determinants in Vibrio cholerae requires toxR". Journal of Bacteriology. 170 (6): 2575–2583. doi:10.1128/jb.170.6.2575-2583.1988. PMC 211174. PMID 2836362.
  9. Miller, V L; Falkow, S (1988). "Evidence for two genetic loci in Yersinia enterocolitica that can promote invasion of epithelial cells". Infection and Immunity. 56 (5): 1242–1248. doi:10.1128/iai.56.5.1242-1248.1988. ISSN 0019-9567. PMC 259798. PMID 2833444.
  10. Miller, V L; Farmer, J J; Hill, W E; Falkow, S (1989). "The ail locus is found uniquely in Yersinia enterocolitica serotypes commonly associated with disease". Infection and Immunity. 57 (1): 121–131. doi:10.1128/iai.57.1.121-131.1989. ISSN 0019-9567. PMC 313052. PMID 2642465.
  11. Hong, K. Heran; Miller, Virginia L. (1998). "Identification of a Novel Salmonella Invasion Locus Homologous to Shigella ipgDE". Journal of Bacteriology. 180 (7): 1793–1802. doi:10.1128/JB.180.7.1793-1802.1998. ISSN 0021-9193. PMC 107092. PMID 9537377.
  12. Darwin, K. Heran; Miller, Virginia L. (1999). "Molecular Basis of the Interaction of Salmonella with the Intestinal Mucosa". Clinical Microbiology Reviews. 12 (3): 405–428. doi:10.1128/CMR.12.3.405. ISSN 0893-8512. PMC 100246. PMID 10398673.
  13. Lawlor, Matthew S.; Hsu, James; Rick, Paul D.; Miller, Virginia L. (2005). "Identification of Klebsiella pneumoniae virulence determinants using an intranasal infection model: Klebsiella pneumoniae intranasal STM". Molecular Microbiology. 58 (4): 1054–1073. doi:10.1111/j.1365-2958.2005.04918.x. PMID 16262790. S2CID 44666800.
  14. Lawlor, Matthew S.; O'Connor, Christopher; Miller, Virginia L. (2007). "Yersinia bactin Is a Virulence Factor for Klebsiella pneumoniae during Pulmonary Infection". Infection and Immunity. 75 (3): 1463–1472. doi:10.1128/IAI.00372-06. ISSN 0019-9567. PMC 1828572. PMID 17220312.
  15. "Virginia L. Miller, Ph.D." Pew Trusts. Retrieved 2021-11-30.{{cite web}}: CS1 maint: url-status (link)
  16. "American Academy of Microbiology fellows". Retrieved December 3, 2021.{{cite web}}: CS1 maint: url-status (link)


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