Tropheryma whipplei

"Tropheryma whipplei", formerly called "Tropheryma whippelii",[4] is a bacterium and the causative organism of Whipple's disease,[3] and rarely, endocarditis.

"Tropheryma whipplei"
Scientific classification
Domain:
Bacteria
Phylum:
Actinomycetota
Class:
Actinomycetia
Order:
Micrococcales
Family:
"Tropherymataceae"

Nouioui et al. 2018[1]
Genus:
"Tropheryma"[2]

La Scola et al. 2001[3]
Species:
"T. whipplei"
Binomial name
"Tropheryma whipplei"
La Scola et al. 2001[3]
Synonyms

"Tropheryma whippelii" Relman et al. 1992

While "T. whipplei" is categorized with the Gram-positive Actinomycetota, the organism is commonly found to be Gram-positive or Gram-indeterminate when stained in the laboratory.[3] Whipple himself probably observed the organisms as rod-shaped structures with silver stain in his original case.[5]

History of the name

No name was given to the organism until 1991, when the name "Tropheryma whippelii" was proposed after sections of the bacterial genome were sequenced.[6] The name was changed to Tropheryma whipplei in 2001 (correcting the spelling of Whipple's name) when the organism was deposited in bacterial collections.[3]

Pathogenesis
Main article: Whipple's disease

Genome structure

Several strains of "T. whipplei" have been sequenced.[7][8]

Genomes of intracellular or parasitic bacteria undergo massive reduction compared to their free-living relatives. With a genome size of less than 1 Mb, T. whipplei is a prime example of genome reduction among Actinomycetota. Other such examples include Mycoplasma for Firmicutes (the low G+C content Gram-positive), Rickettsia for alpha proteobacteria, and Wigglesworthia and Buchnera for gamma proteobacteria.[9]

Some of the largest virions like Megavirus chilensis, Pandoravirus, Pithovirus and mimivirus are comparable in size to miniature bacteria like T. whipplei and Rickettsia conorii.

References
  1. Nouioui I, Carro L, García-López M, Meier-Kolthoff JP, Woyke T, Kyrpides NC, Pukall R, Klenk H-P, Goodfellow M, Markus Göker M. (2018). "Genome-Based Taxonomic Classification of the Phylum Actinobacteria". Front. Microbiol. 9: 2007. doi:10.3389/fmicb.2018.02007. PMC 6113628. PMID 30186281.{{cite journal}}: CS1 maint: uses authors parameter (link)
  2. From Greek τροφή trophê, "nourishment, food" and ἔρυμα eruma, "fence, a defence against, barrier".
  3. La Scola B, Fenollar F, Fournier PE, Altwegg M, Mallet MN, Raoult D (July 2001). "Description of Tropheryma whipplei gen. nov., sp. nov., the Whipple's disease bacillus". Int. J. Syst. Evol. Microbiol. 51 (Pt 4): 1471–9. doi:10.1099/00207713-51-4-1471. PMID 11491348.
  4. Liang Z, La Scola B, Raoult D (January 2002). "Monoclonal antibodies to immunodominant epitope of Tropheryma whipplei". Clin. Diagn. Lab. Immunol. 9 (1): 156–9. doi:10.1128/CDLI.9.1.156-159.2002. PMC 119894. PMID 11777846.
  5. Whipple GH. (1907). "A hitherto undescribed disease characterized anatomically by deposits of fat and fatty acids in the intestinal and mesenteric lymphatic tissues". Johns Hopkins Hosp Bull. 18: 382–91.
  6. Relman D, Schmidt T, MacDermott R, Falkow S (1992). "Identification of the uncultured bacillus of Whipple's disease". N Engl J Med. 327 (5): 293–301. doi:10.1056/NEJM199207303270501. PMID 1377787.
  7. Raoult D, et al. (2003). "Tropheryma whipplei Twist: a human pathogenic Actinobacteria with a reduced genome". Genome Res. 13 (8): 1800–9. doi:10.1101/gr.1474603. PMC 403771. PMID 12902375. Retrieved 8 August 2016.
  8. Bentley, SD.; Maiwald, M.; Murphy, LD.; Pallen, MJ.; Yeats, CA.; Dover, LG.; Norbertczak, HT.; Besra, GS.; et al. (Feb 2003). "Sequencing and analysis of the genome of the Whipple's disease bacterium Tropheryma whipplei". Lancet. 361 (9358): 637–44. doi:10.1016/S0140-6736(03)12597-4. PMID 12606174. S2CID 8743326.
  9. https://genome.cshlp.org/content/13/8/1800.full


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