Tara Matise

Tara Matise is an American geneticist who is head of the Laboratory of Computational Genetics at Rutgers University. Her research considers human genetics, data sciences and bioinformation. She serves as director of the National Human Genome Research Institute Genome Sequencing Program, which looks to identify genes that underlie inherited human disease.

Tara Cox Matise
Born
Tara Kathleen Cox
Alma materCornell University
University of Pittsburgh
Scientific career
InstitutionsRutgers University
Rockefeller University
Columbia University
University of Pittsburgh
ThesisAutomated genetic linkage mapping : development and performance assessment of an expert system computer program (1992)

Early life and education

Matise was an undergraduate student at Cornell University, where she studied genetics.[1] She moved to the University of Pittsburgh for graduate studies, where she worked in the Graduate School of Public Health. Matise worked as a postdoctoral fellow at the University of Pittsburgh, Columbia University and Rockefeller University.[1] At Rockefeller, Matise worked under the supervision of Jürg Ott.[1]

Research and career

Matise was appointed to the faculty at Rockefeller University in 1997.[1] She moved to Rutgers University at Associate Professor in 2000, where she was made Head of Computational Genetics in 2014. Her research considers computational genetics and the use of whole genome sequencing. She serves as Head of the Laboratory of Computational Genetics at Rutgers. She was appointed Head of the Computational Genetics Program in the Human Genetics Institute of New Jersey in 2014.[2][3] Matise was the creator of MultiMap, which allowed for the automatic construction of genetic linkages of the human genome.[4] MultiMap eventually become the Rutgers Maps, a wide scale project that looks to establish genetic linkages using map-building software.[5] The maps contain over 28,000 markers (the largest set of publicly available polymorphic markers) and can be used to interpolate the genetic map position of any marker or gene in the genome. RutgersMaps has been used to evaluate the genetic risks of conditions such as schizophrenia and cystic fibrosis, as well as the impact of smoking on the genetic risks of obesity. Her contribution to the understanding the cystic fibrosis transmembrane conductance regulator (CFTR) gene was honored by the Cystic Fibrosis Foundation in 1990.[1]

In 2008, Matise was appointed co-director of the Population Architecture using Genomics and Epidemiology (PAGE) study.[6][7][8] The study was pioneering in its approach to performing globally representative epidemiology.[9] In particular, Matise was responsible for quality control, integration and dissemination.[10][11]

Matise was appointed Director of the National Human Genome Research Institute (NHGRI) Genome Sequencing Program in 2015. The program makes use of genome sequencing to understand the genes that underpin inherited disease.[12]

Selected publications
  • Adam E Locke; Bratati Kahali; Sonja I Berndt; et al. (12 February 2015). "Genetic studies of body mass index yield new insights for obesity biology". Nature. 518 (7538): 197–206. doi:10.1038/NATURE14177. ISSN 1476-4687. PMC 4382211. PMID 25673413. Wikidata Q22305005.
  • Andrew R Wood; Tõnu Esko; Jian Yang; et al. (5 October 2014). "Defining the role of common variation in the genomic and biological architecture of adult human height". Nature Genetics. 46 (11): 1173–1186. doi:10.1038/NG.3097. ISSN 1061-4036. PMC 4250049. PMID 25282103. Wikidata Q34441746.
  • G D Schuler; M S Boguski; E A Stewart; et al. (25 October 1996). "A Gene Map of the Human Genome". Science. 274 (5287): 540-546, 540-6. doi:10.1126/SCIENCE.274.5287.540. ISSN 0036-8075. PMID 8849440. Wikidata Q22065571.
  • Matise TC; Perlin M; Chakravarti A (1 April 1994). "Automated construction of genetic linkage maps using an expert system (MultiMap): a human genome linkage map". Nature Genetics. 6 (4): 384–390. doi:10.1038/NG0494-384. ISSN 1061-4036. PMID 8054979. Wikidata Q52379176.

References
  1. "Dr Tara Matise - Leadership - HGINJ Leadership". hginj.org. Retrieved 2021-10-18.
  2. "Human Genetics Institute of New Jersey". hginj.org. Retrieved 2021-10-18.
  3. "Leadership - HGINJ Leadership". hginj.org. Retrieved 2021-10-18.
  4. Human Genome News. Biomedical and Environmental Information Analysis Section of the Health and Safety Research Division at Oak Ridge National Laboratory. 1989.
  5. Matise, Tara C.; Chen, Fang; Chen, Wenwei; De La Vega, Francisco M.; Hansen, Mark; He, Chunsheng; Hyland, Fiona C. L.; Kennedy, Giulia C.; Kong, Xiangyang; Murray, Sarah S.; Ziegle, Janet S. (2007). "A second-generation combined linkage physical map of the human genome". Genome Research. 17 (12): 1783–1786. doi:10.1101/gr.7156307. ISSN 1088-9051. PMC 2099587. PMID 17989245.
  6. "The PAGE Study". The PAGE Study. Retrieved 2021-10-18.
  7. "2009 News Feature: NHGRI Uses Recovery Act Funds To Accelerate Genome Research To Improve Human Health". Genome.gov. Retrieved 2021-10-18.
  8. Writer, GEN Staff (2008-07-17). "NHGRI Bankrolls $31M to Study the Effects of Genetic Variants on Various Diseases". GEN - Genetic Engineering and Biotechnology News. Retrieved 2021-10-18.
  9. Bien, Stephanie A.; Wojcik, Genevieve L.; Hodonsky, Chani J.; Gignoux, Christopher R.; Cheng, Iona; Matise, Tara C.; Peters, Ulrike; Kenny, Eimear E.; North, Kari E. (2019-08-31). "The Future of Genomic Studies Must Be Globally Representative: Perspectives from PAGE". Annual Review of Genomics and Human Genetics. 20 (1): 181–200. doi:10.1146/annurev-genom-091416-035517. ISSN 1527-8204. PMC 7012212. PMID 30978304.
  10. Matise, Tara C.; Ambite, Jose Luis; Buyske, Steven; Carlson, Christopher S.; Cole, Shelley A.; Crawford, Dana C.; Haiman, Christopher A.; Heiss, Gerardo; Kooperberg, Charles; Marchand, Loic Le; Manolio, Teri A. (2011-08-11). "The Next PAGE in Understanding Complex Traits: Design for the Analysis of Population Architecture Using Genetics and Epidemiology (PAGE) Study". American Journal of Epidemiology. 174 (7): 849–859. doi:10.1093/aje/kwr160. ISSN 1476-6256. PMC 3176830. PMID 21836165.
  11. "Tara Matise". genetics.rutgers.edu. Retrieved 2021-10-18.
  12. "National Human Genome Research Institute Genome Sequencing Program". gsp-hg.rutgers.edu. Retrieved 2021-10-18.
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