S-Adenosylmethioninamine

S-Adenosylmethioninamine (decarboxylated S-adenosyl methionine) is a substrate that is involved in the biosynthesis of polyamines including spermidine, spermine, and thermospermine.[1] S-adenosyl methionine (or SAM) is primarily synthesized in the liver from its precursor, methionine, and is necessary for proper hepatic function. Thus, SAM plays a role in the storage of fat by hepatocytes. Improper levels of SAM may lead to liver diseases in mammals.[2]

S-Adenosylmethioninamine
Names
Preferred IUPAC name
(3-Aminopropyl){[(2S,3S,4R,5R)-5-(6-amino-9H-purin-9-yl)-3,4-dihydroxyoxolan-2-yl]methyl}methylsulfanium
Other names
S-Adenosyl-(5′)-3-methylthiopropylamine, decarboxylated S-adenosyl methionine, (5-Deoxy-5-adenosyl)(3-aminopropyl)methylsulfonium cation
Identifiers
3D model (JSmol)
Abbreviations dAdoMet, dc-SAM
ChEBI
ChemSpider
KEGG
  • InChI=1S/C14H23N6O3S/c1-24(4-2-3-15)5-8-10(21)11(22)14(23-8)20-7-19-9-12(16)17-6-18-13(9)20/h6-8,10-11,14,21-22H,2-5,15H2,1H3,(H2,16,17,18)/q+1/t8-,10-,11-,14-,24?/m1/s1 N
    Key: ZUNBITIXDCPNSD-LSRJEVITSA-N N
  • InChI=1/C14H23N6O3S/c1-24(4-2-3-15)5-8-10(21)11(22)14(23-8)20-7-19-9-12(16)17-6-18-13(9)20/h6-8,10-11,14,21-22H,2-5,15H2,1H3,(H2,16,17,18)/q+1/t8-,10-,11-,14-,24?/m1/s1
    Key: ZUNBITIXDCPNSD-LSRJEVITBK
  • C[S+](CCCN)C[C@@H]1[C@H]([C@H]([C@@H](O1)n2cnc3c2ncnc3N)O)O
Properties
C14H23N6O3S+
Molar mass 355.43582 g/mol
Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa).
N verify (what is YN ?)
Infobox references

See also

References
  1. Takahashi, Taku; Kakehi, Jun-Ichi (2009-10-13). "Polyamines: Ubiquitous polycations with unique roles in growth and stress responses". Annals of Botany. 105 (1): 1–6. doi:10.1093/aob/mcp259. PMC 2794062. PMID 19828463.
  2. Mato, José M.; Martínez-Chantar, M. Luz; Lu, Shelly C. (March 2013). "S-adenosylmethionine metabolism and liver disease". Annals of Hepatology. 12 (2): 183–189. ISSN 1665-2681. PMC 4027041. PMID 23396728.


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