RNF114

RNF114
Identifiers
Aliases	RNF114, PSORS12, ZNF313, ring finger protein 114
External IDs	OMIM: 612451 MGI: 1933159 HomoloGene: 10265 GeneCards: RNF114
Gene location (Human)
Chr.	Chromosome 20 (human)[1]
End	49,953,885 bp[1]
Gene location (Mouse)
Chr.	Chromosome 2 (mouse)[2]
End	167,358,093 bp[2]
RNA expression pattern
	Top expressed in
	testicle; ; glomerulus; ; endometrium; ; kidney tubule; ; palpebral conjunctiva; ; metanephric glomerulus; ; gastrocnemius muscle;
	More reference expression data
	n/a
Gene ontology
Molecular function	ubiquitin conjugating enzyme binding; GO:1904264, GO:1904822, GO:0090622, GO:0090302 ubiquitin protein ligase activity; metal ion binding; ubiquitin-protein transferase activity; transferase activity;
Cellular component	cytoplasm; intracellular anatomical structure; nucleus; cytosol; plasma membrane;
Biological process	multicellular organism development; cell differentiation; positive regulation of proteasomal ubiquitin-dependent protein catabolic process; protein ubiquitination; spermatogenesis; protein polyubiquitination;
	Sources:Amigo / QuickGO
Orthologs
	55905
	81018
	ENSG00000124226
	ENSMUSG00000006418
	Q9Y508
	Q9ET26
	NM_018683
	NM_030743; NM_001356496; NM_001360930
	NP_061153
	NP_109668; NP_001347859
	Wikidata
View/Edit Human	View/Edit Mouse

E3 ubiquitin-protein ligase RNF114 is a protein that in humans is encoded by the RNF114 gene.[5][6]

References

GRCh38: Ensembl release 89: ENSG00000124226 - Ensembl, May 2017
GRCm38: Ensembl release 89: ENSMUSG00000006418 - Ensembl, May 2017
"Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
"Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
Bijlmakers MJ, Kanneganti SK, Barker JN, Trembath RC, Capon F (August 2011). "Functional analysis of the RNF114 psoriasis susceptibility gene implicates innate immune responses to double-stranded RNA in disease pathogenesis". Human Molecular Genetics. 20 (16): 3129–37. doi:10.1093/hmg/ddr215. PMC 3140818. PMID 21571784.
Yang P, Lu Y, Li M, Zhang K, Li C, Chen H, Tao D, Zhang S, Ma Y (June 2014). "Identification of RNF114 as a novel positive regulatory protein for T cell activation". Immunobiology. 219 (6): 432–9. doi:10.1016/j.imbio.2014.02.002. PMID 24631332.

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