Rhomboid-related protein 2
Rhomboid-related protein 2 is a protein that in humans is encoded by the RHBDL2 gene.[5]
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| Aliases | RHBDL2, RRP2, rhomboid like 2 | ||||||||||||||||||||||||
| External IDs | OMIM: 608962 MGI: 3608413 HomoloGene: 49508 GeneCards: RHBDL2 | ||||||||||||||||||||||||
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| Species | Human | Mouse | |||||||||||||||||||||||
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| Location (UCSC) | Chr 1: 38.89 – 38.94 Mb | Chr 4: 123.68 – 123.72 Mb | |||||||||||||||||||||||
| PubMed search | [3] | [4] | |||||||||||||||||||||||
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Function
The protein encoded by this gene is a member of the rhomboid protease family of integral membrane proteins. This family contains proteins that are related to Drosophila rhomboid-1. Members of this family are found in both prokaryotes and eukaryotes and are thought to function as intramembrane serine proteases.
RHBDL2 functions as a sheddase and is localized to the plasma membrane.[6] Known substrates of RHBDL2 include thrombomodulin and epidermal growth factor;[6] profiling of the substrate repertoire of RHBDL2 has identified a number of additional type I membrane proteins substrates, including BCAM, SPINT1, and CLCP1.[7]
References
- GRCh38: Ensembl release 89: ENSG00000158315 - Ensembl, May 2017
- GRCm38: Ensembl release 89: ENSMUSG00000043333 - Ensembl, May 2017
- "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- "Entrez Gene: Rhomboid, veinlet-like 2 (Drosophila)".
- Lichtenthaler SF, Lemberg MK, Fluhrer R (August 2018). "Proteolytic ectodomain shedding of membrane proteins in mammals-hardware, concepts, and recent developments". The EMBO Journal. 37 (15). doi:10.15252/embj.201899456. PMC 6068445. PMID 29976761.
- Johnson N, Březinová J, Stephens E, Burbridge E, Freeman M, Adrain C, Strisovsky K (August 2017). "Quantitative proteomics screen identifies a substrate repertoire of rhomboid protease RHBDL2 in human cells and implicates it in epithelial homeostasis". Scientific Reports. 7 (1): 7283. doi:10.1038/s41598-017-07556-3. PMC 5544772. PMID 28779096.
Further reading
- Adrain C, Strisovsky K, Zettl M, Hu L, Lemberg MK, Freeman M (May 2011). "Mammalian EGF receptor activation by the rhomboid protease RHBDL2". EMBO Reports. 12 (5): 421–7. doi:10.1038/embor.2011.50. PMC 3090019. PMID 21494248.
- Pascall JC, Brown KD (April 2004). "Intramembrane cleavage of ephrinB3 by the human rhomboid family protease, RHBDL2". Biochemical and Biophysical Research Communications. 317 (1): 244–52. doi:10.1016/j.bbrc.2004.03.039. PMID 15047175.
- Cheng TL, Wu YT, Lin HY, Hsu FC, Liu SK, Chang BI, et al. (December 2011). "Functions of rhomboid family protease RHBDL2 and thrombomodulin in wound healing". The Journal of Investigative Dermatology. 131 (12): 2486–94. doi:10.1038/jid.2011.230. PMID 21833011.
- Xu J, Zheng SL, Isaacs SD, Wiley KE, Wiklund F, Sun J, et al. (February 2010). "Inherited genetic variant predisposes to aggressive but not indolent prostate cancer". Proceedings of the National Academy of Sciences of the United States of America. 107 (5): 2136–40. Bibcode:2010PNAS..107.2136X. doi:10.1073/pnas.0914061107. PMC 2836698. PMID 20080650.
- Urban S, Freeman M (June 2003). "Substrate specificity of rhomboid intramembrane proteases is governed by helix-breaking residues in the substrate transmembrane domain". Molecular Cell. 11 (6): 1425–34. doi:10.1016/s1097-2765(03)00181-3. PMID 12820957.
- Urban S, Lee JR, Freeman M (October 2001). "Drosophila rhomboid-1 defines a family of putative intramembrane serine proteases". Cell. 107 (2): 173–82. doi:10.1016/s0092-8674(01)00525-6. PMID 11672525. S2CID 9026083.
- Lei X, Li YM (December 2009). "The processing of human rhomboid intramembrane serine protease RHBDL2 is required for its proteolytic activity". Journal of Molecular Biology. 394 (5): 815–25. doi:10.1016/j.jmb.2009.10.025. PMID 19850051.
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