Neomycin/polymyxin B/hydrocortisone

Neomycin/polymyxin B/hydrocortisone, sold under the brand Otosporin among others, is a medication used to treat otitis externa (swimmer's ear) and certain eye disorders.[1][2] It consists of the antibiotics neomycin and polymyxin B, and the steroid hydrocortisone.[2] It is used as an ear drop or eye drop.[1][2]

Neomycin/polymyxin B/hydrocortisone
Combination of
NeomycinAntibiotic
Polymyxin BAntibiotic
HydrocortisoneGlucocorticoid
Clinical data
Trade namesOtosporin, Cortisporin, others
AHFS/Drugs.comFDA Professional Drug Information
Routes of
administration		Ear drop, ear drop
Legal status
Legal status
Identifiers
CAS Number
KEGG

The most common side effects include itchiness and a skin rash.[3] Other side effects may include dizziness, hives, anaphylaxis, hearing loss, and headache.[1][3] Safety in pregnancy and breastfeeding is unclear.[4] The antibiotics work by killing specific types of bacteria while the steroids work by decreasing inflammation.[5]

The combination was approved for medical use in the United States in 1964.[2] In 2017, it was the 304th most commonly prescribed medication in the United States, with more than one million prescriptions.[6]

History

Cortisporin was developed by Glaxo Wellcome and was approved by the Food and Drug Administration in 1975. In 1997, the rights were sold to Monarch Pharmaceuticals, a division of King Pharmaceuticals. In 2007, King sold it to JHP Pharmaceuticals. Par Pharmaceutical acquired JHP in 2014. In 2015, Endo International purchased Par.[7]

Cost

In David Lazarus' February 4, 2016 LA Times column, a pharmacist recalled a 10 milliliter vial of the drug selling for around $10 in the early 2010s. In 2015, the price was $100, and in 2016, it reportedly was selling for $195. A generic version is priced at $144.[7] The drug is owned by Dublin, Ireland-based Endo International.

Formulations

Generic name: neomycin sulfate, polymyxin B sulfate, and hydrocortisone
Dosage form: otic suspension (liquid with ear dropper)
Generic name: neomycin sulfate, polymyxin B sulfate, bacitracin zinc and hydrocortisone
Dosage form: Dermatological ointment, drops

References
  1. British national formulary : BNF 76 (76 ed.). Pharmaceutical Press. 2018. p. 1164. ISBN 9780857113382.
  2. "Neomycin, Polymyxin B, Hydrocortisone Ophthalmic Suspension - FDA prescribing information, side effects and uses". Drugs.com. Retrieved 19 April 2019.
  3. "Hydrocortisone/neomycin/polymyxin b otic Side Effects in Detail". Drugs.com. Retrieved 19 April 2019.
  4. "Hydrocortisone / neomycin / polymyxin b otic Use During Pregnancy". Drugs.com. Retrieved 19 April 2019.
  5. "DailyMed - neomycin sulfate, polymyxin b sulfate and hydrocortisone solution". dailymed.nlm.nih.gov. Retrieved 19 April 2019.
  6. "Neomycin; Polymyxin B; Hydrocortisone - Drug Usage Statistics". ClinCalc. Retrieved 11 April 2020.
  7. David L (2016-02-04). "Martin Shkreli isn't alone in ripping off patients with crazy drug prices". latimes.com. Retrieved 2016-02-05.
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