NAV2
Neuron navigator 2 is a protein that in humans is encoded by the NAV2 gene.[5][6][7]
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| Aliases | NAV2, HELAD1, POMFIL2, RAINB1, STEERIN2, UNC53H2, neuron navigator 2 | ||||||||||||||||||||||||
| External IDs | OMIM: 607026 MGI: 2183691 HomoloGene: 52330 GeneCards: NAV2 | ||||||||||||||||||||||||
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| Species | Human | Mouse | |||||||||||||||||||||||
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| Location (UCSC) | Chr 11: 19.35 – 20.12 Mb | Chr 7: 48.91 – 49.61 Mb | |||||||||||||||||||||||
| PubMed search | [3] | [4] | |||||||||||||||||||||||
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The vitamin A metabolite, all-trans retinoic acid (atRA), plays an important role in neuronal development, including neurite outgrowth. RAINB1 is an atRA-responsive gene.[7]
The neuron navigator, Is also theorized to play a role in cellular growth and migration[8]. In addition, different isoform variants have been discovered for this gene. Connections have been drawn to Nav2 having an association with human neurocognitive disorders Alzheimer's disease and age-related phenotypes. It has been discussed that future studies of Nav2 could provide crucial information in understanding the pathophysiology of the disease and its related phenotypes[9].
References
Xu, Chun; Su, Brenda Bin; Lozano, Stephanie; Wang, Kesheng (2020-01-01), Martin, Colin R.; Preedy, Victor R. (eds.), "Chapter 1 - The neuron navigator 2 gene and Alzheimer's disease", Genetics, Neurology, Behavior, and Diet in Dementia, Academic Press, pp. 3–24, ISBN 978-0-12-815868-5, retrieved 2022-05-05
- GRCh38: Ensembl release 89: ENSG00000166833 - Ensembl, May 2017
- GRCm38: Ensembl release 89: ENSMUSG00000052512 - Ensembl, May 2017
- "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- Maes T, Barcelo A, Buesa C (Jun 2002). "Neuron navigator: a human gene family with homology to unc-53, a cell guidance gene from Caenorhabditis elegans". Genomics. 80 (1): 21–30. doi:10.1006/geno.2002.6799. PMID 12079279.
- Coy JF, Wiemann S, Bechmann I, Bachner D, Nitsch R, Kretz O, Christiansen H, Poustka A (Jun 2002). "Pore membrane and/or filament interacting like protein 1 (POMFIL1) is predominantly expressed in the nervous system and encodes different protein isoforms". Gene. 290 (1–2): 73–94. doi:10.1016/S0378-1119(02)00567-X. PMID 12062803.
- "Entrez Gene: NAV2 neuron navigator 2".
- "NAV2 neuron navigator 2 [Homo sapiens (human)] - Gene - NCBI". www.ncbi.nlm.nih.gov. Retrieved 2022-05-05.
- Xu, Chun; Su, Brenda Bin; Lozano, Stephanie; Wang, Kesheng (2020-01-01), Martin, Colin R.; Preedy, Victor R. (eds.), "Chapter 1 - The neuron navigator 2 gene and Alzheimer's disease", Genetics, Neurology, Behavior, and Diet in Dementia, Academic Press, pp. 3–24, ISBN 978-0-12-815868-5, retrieved 2022-05-05
Further reading
- Nakajima D, Okazaki N, Yamakawa H, et al. (2003). "Construction of expression-ready cDNA clones for KIAA genes: manual curation of 330 KIAA cDNA clones". DNA Res. 9 (3): 99–106. doi:10.1093/dnares/9.3.99. PMID 12168954.
- Hillier LD, Lennon G, Becker M, et al. (1997). "Generation and analysis of 280,000 human expressed sequence tags". Genome Res. 6 (9): 807–28. doi:10.1101/gr.6.9.807. PMID 8889549.
- Nagase T, Kikuno R, Ishikawa KI, et al. (2000). "Prediction of the coding sequences of unidentified human genes. XVI. The complete sequences of 150 new cDNA clones from brain which code for large proteins in vitro". DNA Res. 7 (1): 65–73. doi:10.1093/dnares/7.1.65. PMID 10718198.
- Dias Neto E, Correa RG, Verjovski-Almeida S, et al. (2000). "Shotgun sequencing of the human transcriptome with ORF expressed sequence tags". Proc. Natl. Acad. Sci. U.S.A. 97 (7): 3491–6. Bibcode:2000PNAS...97.3491D. doi:10.1073/pnas.97.7.3491. PMC 16267. PMID 10737800.
- Merrill RA, Plum LA, Kaiser ME, Clagett-Dame M (2002). "A mammalian homolog of unc-53 is regulated by all-trans retinoic acid in neuroblastoma cells and embryos". Proc. Natl. Acad. Sci. U.S.A. 99 (6): 3422–7. Bibcode:2002PNAS...99.3422M. doi:10.1073/pnas.052017399. PMC 122539. PMID 11904404.
- Ishiguro H, Shimokawa T, Tsunoda T, et al. (2002). "Isolation of HELAD1, a novel human helicase gene up-regulated in colorectal carcinomas". Oncogene. 21 (41): 6387–94. doi:10.1038/sj.onc.1205751. PMID 12214280.
- Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
- Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
- Mitin NY, Ramocki MB, Zullo AJ, et al. (2004). "Identification and characterization of rain, a novel Ras-interacting protein with a unique subcellular localization". J. Biol. Chem. 279 (21): 22353–61. doi:10.1074/jbc.M312867200. PMID 15031288.
- Tsutsumi S, Kamata N, Vokes TJ, et al. (2004). "The Novel Gene Encoding a Putative Transmembrane Protein Is Mutated in Gnathodiaphyseal Dysplasia (GDD)". Am. J. Hum. Genet. 74 (6): 1255–61. doi:10.1086/421527. PMC 1182089. PMID 15124103.
- Peeters PJ, Baker A, Goris I, et al. (2004). "Sensory deficits in mice hypomorphic for a mammalian homologue of unc-53". Brain Res. Dev. Brain Res. 150 (2): 89–101. doi:10.1016/j.devbrainres.2004.03.004. PMID 15158073.
- Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
- Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. Bibcode:2005Natur.437.1173R. doi:10.1038/nature04209. PMID 16189514. S2CID 4427026.
- Beausoleil SA, Villén J, Gerber SA, et al. (2006). "A probability-based approach for high-throughput protein phosphorylation analysis and site localization". Nat. Biotechnol. 24 (10): 1285–92. doi:10.1038/nbt1240. PMID 16964243. S2CID 14294292.
- Olsen JV, Blagoev B, Gnad F, et al. (2006). "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks". Cell. 127 (3): 635–48. doi:10.1016/j.cell.2006.09.026. PMID 17081983. S2CID 7827573.
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