Ipratropium bromide/salbutamol
Ipratropium bromide/salbutamol, sold under the brand name Combivent among others, is a combination medication used to treat chronic obstructive pulmonary disease (COPD).[1][2][3] It contains ipratropium (an anticholinergic) and salbutamol (albuterol, a β2-adrenergic agonist).[1] It is taken by inhalation.[4]
Combination of | |
---|---|
Ipratropium bromide | Muscarinic antagonist |
Salbutamol | Short-acting β2-adrenergic agonist |
Clinical data | |
Trade names | Combivent, DuoNeb, Breva, others |
AHFS/Drugs.com | Professional Drug Facts |
MedlinePlus | a601063 |
License data | |
Routes of administration | Inhalation |
ATC code | |
Legal status | |
Legal status | |
Identifiers | |
CAS Number | |
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Common side effects include sore throat, muscle cramps, and nausea.[1] Other side effects may include bronchospasm, allergic reactions, and upper respiratory tract infections.[1] Safety in pregnancy is unclear.[5] Each medication typically decreases bronchospasm and does so via different mechanisms.[1]
The combination was approved for medical use in the United States in 1996.[4] It is available as a generic medication.[2] In 2019, it was the 151st most commonly prescribed medication in the United States, with more than 4 million prescriptions.[6][7]
Society and culture
Since Combivent contains a chlorofluorocarbon-based propellant, it is being phased out in European Union countries. Chloroflourocarbons (CFC) are attributed to depletion of the ozone layer.
References
- "DailyMed - ipratropium bromide and albuterol sulfate inhalant". dailymed.nlm.nih.gov. Retrieved 18 April 2019.
- British national formulary : BNF 76 (76 ed.). Pharmaceutical Press. 2018. p. 247. ISBN 9780857113382.
- Gordon J, Panos RJ (March 2010). "Inhaled albuterol/salbutamol and ipratropium bromide and their combination in the treatment of chronic obstructive pulmonary disease". Expert Opinion on Drug Metabolism & Toxicology. 6 (3): 381–92. doi:10.1517/17425251003649549. PMID 20163324. S2CID 31806856.
- "Ipratropium and Albuterol - FDA prescribing information, side effects and uses". Drugs.com. Retrieved 18 April 2019.
- "Albuterol / ipratropium Use During Pregnancy". Drugs.com. Retrieved 19 April 2019.
- "The Top 300 of 2019". ClinCalc. Retrieved 16 October 2021.
- "Albuterol; Ipratropium - Drug Usage Statistics". ClinCalc. Retrieved 16 October 2021.
External links
- DailyMed
- Consumer Medication Information from PubMed Archived 2012-12-03 at the Wayback Machine
- Expert Panel Report 3: Guidelines for the Diagnosis and Management of Asthma. National Heart, Lung, and Blood Institute. 2007.