E1210

E1210 is an isoxazole-based broad-spectrum antifungal.[1] E1210 targets GPI-protein biosynthesis.

E1210
Names
Preferred IUPAC name
6-Oxa-1(3),7(2)-dipyridina-2(5,3)-[1,2]oxazola-4(1,4)-benzenaheptaphan-12-amine
Identifiers
3D model (JSmol)
ChEMBL
ChemSpider
UNII
  • InChI=1S/C21H18N4O2/c22-21-18(4-3-11-24-21)19-13-17(25-27-19)12-15-6-8-16(9-7-15)14-26-20-5-1-2-10-23-20/h1-11,13H,12,14H2,(H2,22,24)
    Key: WSEKTEUGRLFBSE-UHFFFAOYSA-N
  • InChI=1/C21H18N4O2/c22-21-18(4-3-11-24-21)19-13-17(25-27-19)12-15-6-8-16(9-7-15)14-26-20-5-1-2-10-23-20/h1-11,13H,12,14H2,(H2,22,24)
    Key: WSEKTEUGRLFBSE-UHFFFAOYAO
  • c1ccnc(c1)OCc2ccc(cc2)Cc3cc(on3)c4cccnc4N
Properties
C12H18N4O2
Molar mass 250.302 g·mol−1
Hazards
GHS labelling:
Warning
H302, H411
P264, P270, P273, P301+P312, P330, P391, P501
Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa).
Infobox references

References

  1. Pfaller, Michael A.; Hata, Katsura; Jones, Ronald N.; Messer, Shawn A.; Moet, Gary J.; Castanheira, Mariana (2011). "In vitro activity of a novel broad-spectrum antifungal, E1210, tested against Candida SPP. As determined by CLSI broth microdilution method". Diagnostic Microbiology and Infectious Disease. 71 (2): 167–170. doi:10.1016/j.diagmicrobio.2011.05.001. PMID 21696907.
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