Calmegin

CLGN
Identifiers
Aliases	CLGN, calmegin
External IDs	OMIM: 601858 MGI: 107472 HomoloGene: 68392 GeneCards: CLGN
Gene location (Human)
Chr.	Chromosome 4 (human)[1]
End	140,427,661 bp[1]
Gene location (Mouse)
Chr.	Chromosome 8 (mouse)[2]
End	84,155,181 bp[2]
RNA expression pattern
	Top expressed in
	testicle; ; right ventricle; ; myocardium; ; left ventricle; ; heart; ; retinal pigment epithelium;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	unfolded protein binding; protein folding chaperone; calcium ion binding; GO:0001948 protein binding;
Cellular component	integral component of membrane; endoplasmic reticulum membrane; membrane; endoplasmic reticulum; nuclear envelope;
Biological process	protein folding; single fertilization; binding of sperm to zona pellucida; protein-containing complex assembly;
	Sources:Amigo / QuickGO
Orthologs
	1047
	12745
	ENSG00000153132
	ENSMUSG00000002190
	O14967
	P52194
	NM_001130675; NM_004362
	NM_009904; NM_001329627; NM_001329680
	NP_001124147; NP_004353
	NP_001316556; NP_001316609; NP_034034
	Wikidata
View/Edit Human	View/Edit Mouse

Calmegin, also known as CLGN, is a protein which in humans is encoded by the CLGN gene.[5] Calmegin is also present in other animals including mice.[6]

Function

Calmegin is a testis-specific endoplasmic reticulum chaperone protein. CLGN may play a role in spermatogeneisis and infertility.[5]

References

GRCh38: Ensembl release 89: ENSG00000153132 - Ensembl, May 2017
GRCm38: Ensembl release 89: ENSMUSG00000002190 - Ensembl, May 2017
"Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
"Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
"Entrez Gene: CLGN calmegin".
Watanabe D, Yamada K, Nishina Y, Tajima Y, Koshimizu U, Nagata A, Nishimune Y (March 1994). "Molecular cloning of a novel Ca(2+)-binding protein (calmegin) specifically expressed during male meiotic germ cell development". J. Biol. Chem. 269 (10): 7744–7749. doi:10.1016/S0021-9258(17)37349-0. PMID 8126001.

Watanabe D, Yamada K, Nishina Y, et al. (1994). "Molecular cloning of a novel Ca(2+)-binding protein (calmegin) specifically expressed during male meiotic germ cell development". J. Biol. Chem. 269 (10): 7744–7749. doi:10.1016/S0021-9258(17)37349-0. PMID 8126001.
Ikawa M, Wada I, Kominami K, et al. (1997). "The putative chaperone calmegin is required for sperm fertility". Nature. 387 (6633): 607–611. Bibcode:1997Natur.387..607I. doi:10.1038/42484. PMID 9177349. S2CID 4347203.
Tanaka H, Ikawa M, Tsuchida J, et al. (1998). "Cloning and characterization of the human Calmegin gene encoding putative testis-specific chaperone". Gene. 204 (1–2): 159–163. doi:10.1016/S0378-1119(97)00537-4. PMID 9434179.
Yoshinaga K, Tanii I, Toshimori K (1999). "Molecular chaperone calmegin localization to the endoplasmic reticulum of meiotic and post-meiotic germ cells in the mouse testis". Arch. Histol. Cytol. 62 (3): 283–293. doi:10.1679/aohc.62.283. PMID 10495883.
Ikawa M, Nakanishi T, Yamada S, et al. (2002). "Calmegin is required for fertilin alpha/beta heterodimerization and sperm fertility". Dev. Biol. 240 (1): 254–261. doi:10.1006/dbio.2001.0462. PMID 11784061.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–16903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–45. doi:10.1038/ng1285. PMID 14702039.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–2127. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–1178. Bibcode:2005Natur.437.1173R. doi:10.1038/nature04209. PMID 16189514. S2CID 4427026.
Kim DH, Shim JS, Kwon HJ (2005). "Coordinated transcriptional regulation of calmegin,a testis-specific molecular chaperon, by histone deacetylase and CpG methyltransferase". Experimental & Molecular Medicine. 37 (5): 492–496. doi:10.1038/emm.2005.61. PMID 16264275.
Olsen JV, Blagoev B, Gnad F, et al. (2006). "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks". Cell. 127 (3): 635–648. doi:10.1016/j.cell.2006.09.026. PMID 17081983. S2CID 7827573.

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[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000153132 - Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000002190 - Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[entrez-5] "Entrez Gene: CLGN calmegin".

[pmid8126001-6] Watanabe D, Yamada K, Nishina Y, Tajima Y, Koshimizu U, Nagata A, Nishimune Y (March 1994). "Molecular cloning of a novel Ca(2+)-binding protein (calmegin) specifically expressed during male meiotic germ cell development". J. Biol. Chem. 269 (10): 7744–7749. doi:10.1016/S0021-9258(17)37349-0. PMID 8126001.

Calmegin

Function

References

Further reading