Barbara Ramsay Shaw

Barbara Ramsay Shaw is the William T. Miller Distinguished Emeritus Professor of Chemistry at Duke University. She is known for her work on how DNA reacts with other compounds.

Barbara Ramsay Shaw
Born
Newton, New Jersey
Alma materUniversity of Washington, Bryn Mawr College
Scientific career
InstitutionsDuke University
Doctoral advisorsMichael Schurr and Walter Kauzmann
Doctoral studentsLawrence C Sowers, Robert Reynolds, Kenneth Porter, Loren Williams, Lisa (Frederico) Zuraw, Faqing Huang, Randall Richards, Mark Zottola, Kaizhang He, Jinlai Lin, Joy Wang, Hongyan Liu, Charlotta Wennefors, Laura Moussa, Mariam Sharaf, Marcus Cheek

Education and career

Shaw obtained her B.A. from Bryn Mawr College in 1965. She has an M.S. (1967) and a Ph.D. (1973) from the University of Washington.[1] Her Ph.D. advisors were Michael Schurr of the University of Washington and Walter Kauzmann of Princeton University. Shaw obtained her post-doctoral training in the laboratory of Kensal van Holde at Oregon State University. In 1975 Shaw moved to Duke University as an assistant professor, and by 1992 she had been promoted to full professor.[1] In 2006 Shaw was named the William T Miller Professor of Chemistry at Duke University.[2]

Research

Shaw is known for her work on boranophosphates.[3] While a postdoctoral researcher at Oregon State she helped establish the structure of the nucleosome.[4] She has studied the chemical reactivity of DNA, and applied synthetic chemistry to gene expression, signal transduction, and cancer treatment.[5]

Awards and honors

Shaw was the first recipient from Duke University of the Camille Dreyfus Teacher-Scholar Award.[6] In 1987, the YWCA in North Carolina named Shaw as one of their "women of achievement".[7]

Selected publications
  • Li, Ping; Sergueeva, Zinaida A.; Dobrikov, Mikhail; Shaw, Barbara Ramsay (1 November 2007). "Nucleoside and Oligonucleoside Boranophosphates: Chemistry and Properties". Chemical Reviews. 107 (11): 4746–4796. doi:10.1021/cr050009p. PMID 17967037.
  • Frederico, Lisa A.; Kunkel, Thomas A.; Shaw, Barbara Ramsay (1 March 1990). "A sensitive genetic assay for the detection of cytosine deamination: determination of rate constants and the activation energy". Biochemistry. 29 (10): 2532–2537. doi:10.1021/bi00462a015.
  • Williams, L D; Shaw, B R (1987). "Protonated base pairs explain the ambiguous pairing properties of O6-methylguanine". Proceedings of the National Academy of Sciences. 84 (7): 1779–1783. doi:10.1073/pnas.84.7.1779. ISSN 0027-8424. PMC 304524. PMID 3470757.
  • Shaw, B R; Herman, T M; Kovacic, R T; Beaudreau, G S; Van Holde, K E (1976). "Analysis of subunit organization in chicken erythrocyte chromatin". Proceedings of the National Academy of Sciences. 73 (2): 505–509. doi:10.1073/pnas.73.2.505. ISSN 0027-8424. PMC 335938. PMID 1061151.

References
  1. "Barbara R. Shaw | Scholars@Duke". web.archive.org. 2021-05-06. Retrieved 2022-04-27.
  2. "Chemistry News Archives". Duke University. Retrieved May 31, 2009.
  3. Li, Ping; Sergueeva, Zinaida A.; Dobrikov, Mikhail; Shaw, Barbara Ramsay (1 November 2007). "Nucleoside and Oligonucleoside Boranophosphates: Chemistry and Properties". Chemical Reviews. 107 (11): 4746–4796. doi:10.1021/cr050009p. PMID 17967037.
  4. Van Hoide, K.E.; Sahasrabuddhe, C.G.; Shaw, Barbara Ramsay (1974). "A model for particulate structure in chromatin". Nucleic Acids Research. 1 (11): 1579–1586. doi:10.1093/nar/1.11.1579. PMC 343437. PMID 10793713.
  5. Frederico, Lisa A.; Kunkel, Thomas A.; Shaw, Barbara Ramsay (1 March 1990). "A sensitive genetic assay for the detection of cytosine deamination: determination of rate constants and the activation energy". Biochemistry. 29 (10): 2532–2537. doi:10.1021/bi00462a015.
  6. "Dreyfus award recipients" (PDF). 2021.
  7. Hodges, Betty (1987-03-01). "Women of achievement". The Herald-Sun. pp. , . Retrieved 2022-04-27.
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