BAT5

ABHD16A
Identifiers
Aliases	ABHD16A, BAT5, D6S82E, NG26, PP199, abhydrolase domain containing 16A, hBAT5, abhydrolase domain containing 16A, phospholipase, SPG86
External IDs	OMIM: 142620 MGI: 99476 HomoloGene: 10904 GeneCards: ABHD16A
Gene location (Human)
Chr.	Chromosome 6 (human)[1]
End	31,703,356 bp[1]
Gene location (Mouse)
Chr.	Chromosome 17 (mouse)[2]
End	35,321,963 bp[2]
RNA expression pattern
	Top expressed in
	pituitary gland; ; anterior pituitary; ; right lobe of thyroid gland; ; right uterine tube; ; Ganglionic eminence; ; spleen; ; left lobe of thyroid gland; ; blood; ; left uterine tube; ; prostate;
	More reference expression data
	n/a
Gene ontology
Molecular function	GO:0001948 protein binding; hydrolase activity; lysophospholipase activity; acylglycerol lipase activity; phospholipase activity;
Cellular component	membrane; integral component of membrane;
Biological process	monoacylglycerol catabolic process; prostaglandin catabolic process; phosphatidylserine catabolic process; lipid metabolism;
	Sources:Amigo / QuickGO
Orthologs
	7920
	193742
ENSG00000236063; ENSG00000231488; ENSG00000204427; ENSG00000235676; ENSG00000230475;
	ENSG00000206403; ENSG00000224552
	ENSMUSG00000007036
	O95870
	Q9Z1Q2
	NM_001177515; NM_021160
	NM_178592
	NP_001170986; NP_066983
	NP_848707
	Wikidata
View/Edit Human	View/Edit Mouse

Protein BAT5 is a protein that in humans is encoded by the BAT5 gene.[5][6][7]

A cluster of genes, BAT1-BAT5, has been localized in the vicinity of the genes for TNF alpha and TNF beta. These genes are all within the human major histocompatibility complex class III region. The protein encoded by this gene is thought to be involved in some aspects of immunity.[7]

Bat5 structure

Amino Acid Sequence

Cross examination of BAT5 Amino Acid sequence in humans and mice

BAT5 (also known as ABHD16A) has been found to be 558 amino acid residues. It was fist identified in 1992 in the gene domain of TNF alpha and TNF beta. BAT5 (ABHD 16A) in different species has been found to be different lengths of amino acid sequence.

Structural prediction of human BAT5 (ABHD 16A) protein

BAT5 has been determined to be highly conserved when compared to human, mice and other mammalian ontologies.[8] It is found to be expressed in multiple different tissue cells. According to molecular evolutionary genetic analysis, in comparison of 13 mammalian species, the noticeable differences in amino acid sequence length is due to splicing in post transcriptional processing of mRNA.[9]

Human chromosome 6 and Mouse chromosome 17 BAT5 location

BAT5 gene location

Human Bat5 (ABHD16A) is located on chromosome 6. Mice Bat5 (ABHD 16A) is located between TNF and Heat shock protein near the Ck2b protein kinase gene.[9]

BAT5 molecular weight

BAT5 molecular weight comparison of Humans (H) and Mice (m)

BAT5 in humans and mice has been found to be around 63kDA.

Bat5 implications in recent studies

BAT5 has been linked to neurological, immune regulation, Kawasaki's disease and coronary artery disease.[9]

References

ENSG00000231488, ENSG00000204427, ENSG00000235676, ENSG00000230475, ENSG00000206403, ENSG00000224552 GRCh38: Ensembl release 89: ENSG00000236063, ENSG00000231488, ENSG00000204427, ENSG00000235676, ENSG00000230475, ENSG00000206403, ENSG00000224552 - Ensembl, May 2017
GRCm38: Ensembl release 89: ENSMUSG00000007036 - Ensembl, May 2017
"Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
"Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
Spies T, Blanck G, Bresnahan M, Sands J, Strominger JL (Feb 1989). "A new cluster of genes within the human major histocompatibility complex". Science. 243 (4888): 214–7. Bibcode:1989Sci...243..214S. doi:10.1126/science.2911734. PMID 2911734.
Spies T, Bresnahan M, Strominger JL (Dec 1989). "Human major histocompatibility complex contains a minimum of 19 genes between the complement cluster and HLA-B". Proc Natl Acad Sci U S A. 86 (22): 8955–8. Bibcode:1989PNAS...86.8955S. doi:10.1073/pnas.86.22.8955. PMC 298409. PMID 2813433.
"Entrez Gene: BAT5 HLA-B associated transcript 5".
Savinainen, Juha R.; Patel, Jayendra Z.; Parkkari, Teija; Navia-Paldanius, Dina; Marjamaa, Joona J. T.; Laitinen, Tuomo; Nevalainen, Tapio; Laitinen, Jarmo T. (2014-10-07). "Biochemical and Pharmacological Characterization of the Human Lymphocyte Antigen B-Associated Transcript 5 (BAT5/ABHD16A)". PLOS ONE. 9 (10): e109869. doi:10.1371/journal.pone.0109869. ISSN 1932-6203.
Xu, Jun; Gu, Weizhen; Ji, Kai; Xu, Zhao; Zhu, Haihua; Zheng, Wenming. "Sequence analysis and structure prediction of ABHD16A and the roles of the ABHD family members in human disease". Open Biology. 8 (5): 180017. doi:10.1098/rsob.180017. PMC 5990648. PMID 29794032.

External links

Human ABHD16A genome location and ABHD16A gene details page in the UCSC Genome Browser.

Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
Gevaert K, Goethals M, Martens L, et al. (2004). "Exploring proteomes and analyzing protein processing by mass spectrometric identification of sorted N-terminal peptides". Nat. Biotechnol. 21 (5): 566–9. doi:10.1038/nbt810. PMID 12665801. S2CID 23783563.
Mungall AJ, Palmer SA, Sims SK, et al. (2003). "The DNA sequence and analysis of human chromosome 6". Nature. 425 (6960): 805–11. Bibcode:2003Natur.425..805M. doi:10.1038/nature02055. PMID 14574404.
Xie T, Rowen L, Aguado B, et al. (2004). "Analysis of the Gene-Dense Major Histocompatibility Complex Class III Region and Its Comparison to Mouse". Genome Res. 13 (12): 2621–36. doi:10.1101/gr.1736803. PMC 403804. PMID 14656967.
Lehner B, Semple JI, Brown SE, et al. (2004). "Analysis of a high-throughput yeast two-hybrid system and its use to predict the function of intracellular proteins encoded within the human MHC class III region". Genomics. 83 (1): 153–67. doi:10.1016/S0888-7543(03)00235-0. PMID 14667819.
Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
Lehner B, Sanderson CM (2004). "A Protein Interaction Framework for Human mRNA Degradation". Genome Res. 14 (7): 1315–23. doi:10.1101/gr.2122004. PMC 442147. PMID 15231747.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
Wan D, Gong Y, Qin W, et al. (2004). "Large-scale cDNA transfection screening for genes related to cancer development and progression". Proc. Natl. Acad. Sci. U.S.A. 101 (44): 15724–9. Bibcode:2004PNAS..10115724W. doi:10.1073/pnas.0404089101. PMC 524842. PMID 15498874.
Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. Bibcode:2005Natur.437.1173R. doi:10.1038/nature04209. PMID 16189514. S2CID 4427026.

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[refGRCh38Ensembl-1] ENSG00000231488, ENSG00000204427, ENSG00000235676, ENSG00000230475, ENSG00000206403, ENSG00000224552 GRCh38: Ensembl release 89: ENSG00000236063, ENSG00000231488, ENSG00000204427, ENSG00000235676, ENSG00000230475, ENSG00000206403, ENSG00000224552 - Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000007036 - Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid2911734-5] Spies T, Blanck G, Bresnahan M, Sands J, Strominger JL (Feb 1989). "A new cluster of genes within the human major histocompatibility complex". Science. 243 (4888): 214–7. Bibcode:1989Sci...243..214S. doi:10.1126/science.2911734. PMID 2911734.

[pmid2813433-6] Spies T, Bresnahan M, Strominger JL (Dec 1989). "Human major histocompatibility complex contains a minimum of 19 genes between the complement cluster and HLA-B". Proc Natl Acad Sci U S A. 86 (22): 8955–8. Bibcode:1989PNAS...86.8955S. doi:10.1073/pnas.86.22.8955. PMC 298409. PMID 2813433.

[entrez-7] "Entrez Gene: BAT5 HLA-B associated transcript 5".

[8] Savinainen, Juha R.; Patel, Jayendra Z.; Parkkari, Teija; Navia-Paldanius, Dina; Marjamaa, Joona J. T.; Laitinen, Tuomo; Nevalainen, Tapio; Laitinen, Jarmo T. (2014-10-07). "Biochemical and Pharmacological Characterization of the Human Lymphocyte Antigen B-Associated Transcript 5 (BAT5/ABHD16A)". PLOS ONE. 9 (10): e109869. doi:10.1371/journal.pone.0109869. ISSN 1932-6203.

[rsob.180017-9] Xu, Jun; Gu, Weizhen; Ji, Kai; Xu, Zhao; Zhu, Haihua; Zheng, Wenming. "Sequence analysis and structure prediction of ABHD16A and the roles of the ABHD family members in human disease". Open Biology. 8 (5): 180017. doi:10.1098/rsob.180017. PMC 5990648. PMID 29794032.