77-LH-28-1

77-LH-28-1
Identifiers
	IUPAC name 1-[3-(4-butylpiperidin-1-yl)propyl]-3,4-dihydroquinolin-2-one;
CAS Number	560085-11-2;
PubChem CID	10236758;
IUPHAR/BPS	3271;
ChemSpider	8412246;
CompTox Dashboard (EPA)	DTXSID90437063 ;
Chemical and physical data
Formula	C21H32N2O
Molar mass	328.500 g·mol−1
3D model (JSmol)	Interactive image;
	SMILES O=C2N(c1ccccc1CC2)CCCN3CCC(CC3)CCCC;
	InChI InChI=1S/C21H32N2O/c1-2-3-7-18-12-16-22(17-13-18)14-6-15-23-20-9-5-4-8-19(20)10-11-21(23)24/h4-5,8-9,18H,2-3,6-7,10-17H2,1H3; Key:PHMGZAICAOYEAF-UHFFFAOYSA-N;

77-LH-28-1 is a selective agonist of muscarinic acetylcholine receptor subtype 1 (M₁) discovered in 2008. It is an allosteric agonist, exhibiting over 100-fold specificity for M₁ over other muscarinic receptor subtypes. 77-LH-28-1 penetrates the brain by crossing the blood-brain barrier and is therefore a useful pharmacological tool with cognition enhancing effects.[1]

References

C J Langmead; N E Austin; C L Branch; J T Brown; K A Buchanan; C H Davies; I T Forbes; V A H Fry; J J Hagan; H J Herdon; G A Jones; R Jeggo; J N C Kew; A Mazzali; R Melarange; N Patel; J Pardoe; A D Randall; C Roberts; A Roopun; K R Starr; A Teriakidis; M D Wood; M Whittington; Z Wu & J Watson (2008). "Characterization of a CNS penetrant, selective M1 muscarinic receptor agonist, 77-LH-28-1". Br J Pharmacol. 154 (5): 1104–1115. doi:10.1038/bjp.2008.152. PMC 2451039. PMID 18454168.

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[1] C J Langmead; N E Austin; C L Branch; J T Brown; K A Buchanan; C H Davies; I T Forbes; V A H Fry; J J Hagan; H J Herdon; G A Jones; R Jeggo; J N C Kew; A Mazzali; R Melarange; N Patel; J Pardoe; A D Randall; C Roberts; A Roopun; K R Starr; A Teriakidis; M D Wood; M Whittington; Z Wu & J Watson (2008). "Characterization of a CNS penetrant, selective M1 muscarinic receptor agonist, 77-LH-28-1". Br J Pharmacol. 154 (5): 1104–1115. doi:10.1038/bjp.2008.152. PMC 2451039. PMID 18454168.