2022 Italian Open – Men's singles

The top eight seeds received a bye into the second round.

Click on the seed number of a player to go to their draw section.

The following are the seeded players. Seedings are based on ATP rankings as of 2 May 2022. Rankings and points before are as of 9 May 2022.

As a result of special ranking adjustment rules due to the COVID-19 pandemic, players are defending the higher of (i) their points from the 2021 tournament or (ii) the remaining 50% of their points from the 2020 tournament. Those points were not mandatory and are included in the table below only if they counted towards the player's ranking as of May 9, 2022. Players who are not defending points from the 2021 or 2020 tournaments will instead have their 19th best result replaced by their points from the 2022 tournament.

Seed	Rank	Player	Points before	Points defending (or 19th best result)†	Points won	Points after	Status
1		Novak Djokovic		600	10		Second round vs.
2		Alexander Zverev		180	10		Second round vs.
3		Rafael Nadal		1,000	10		Second round vs.
4		Stefanos Tsitsipas		180	10		Second round vs.
5		Casper Ruud		180	10		Second round vs.
6		Andrey Rublev		180	10		Second round vs.
7		Carlos Alcaraz		(3)	10		Second round vs.
8		Félix Auger-Aliassime		90	10		Second round vs.
9		Cameron Norrie		70	10		First round vs.
10		Jannik Sinner		45	10		First round vs.
11		Taylor Fritz	2,965	45	10	2,930	First round vs.
12		Hubert Hurkacz		45	10		First round vs.
13		Diego Schwartzman		300	10		First round vs.
14		Denis Shapovalov		180	10		First round vs.
15		Reilly Opelka		360	10		First round vs.
16		Pablo Carreño Busta		45	10		First round vs.

† This column shows either (a) the higher of the player's points from the 2021 tournament or 50% of his points from the 2020 tournament, or (b) his 19th best result (shown in brackets). Only ranking points counting towards the player's ranking as of May 9, 2022, are reflected in the column.

Withdrawn players

The following players would have been seeded, but withdrew before the tournament began.

Rank	Player	Points before	Points defending	Points after	Withdrawal reason
	Daniil Medvedev	7,990	10	7,980	Hernia surgery
	Matteo Berrettini	3,895	90	3,805	Right hand injury

• QUALIFYING
• MAIN DRAW