2021 in South Sudan

• President: Salva Kiir Mayardit
• Vice President: Riek Machar

Ongoing – COVID-19 pandemic in South Sudan, South Sudanese Civil War, Sudanese nomadic conflicts, ethnic violence in South Sudan

• January 15 – South Sudan offers to mediate a border dispute between Sudan and Ethiopia.[1]
• February 4 – Mel Garang, a spokesperson for the South Sudan Hotel and Catering Association, says that hundreds of politicians from different opposition groups, the ruling party, and the military, have been kicked out of 18 hotels in Juba for unpaid bills amounting to US$50 million (€41 million).[2]
• February 16 – United Nations organizations, including the World Health Organization (WHO) and United Nations International Children's Emergency Fund (UNICEF), launch a second round of polio vaccination targeted at 2.8 million children. Workers have been going from house to house using an oral polio vaccine to inoculate children.[3]

• April 2–5 — Easter celebrations.[4]
• May 13 – Eid al-Fitr, Muslim breaking of the Fast.[4]
• May 16 – Sudan People’s Liberation Army Day.[5]
• July 9 – Independence Day, since 2011 (from Sudan).[4]
• July 30 – Martyrs' Day.[4]
• December 26 – Christmas holiday.[4]

• April 5 – Paulino Lukudu Loro, 80, Roman Catholic prelate, bishop of El Obeid (1979–1983) and archbishop of Juba (1983–2019).[6]