2015 Japanese scientific misconduct allegations

The 2015 Japanese scientific misconduct allegations refers to anonymous allegations of scientific misconducts involving over 80 medical life science papers from various Japanese universities,[1] some of it also involving Nobel laureates.

Background

Since around 2000, many scientific fraud cases in Japan were exposed through anonymous Internet postings,[2][3] and anonymous sites such as 2channel began to attract scientific interest.

After a 2006 case at Osaka University in which an assistant professor who was implicated in scientific fraud committed suicide,[4] the Molecular Biology Society of Japan held an educational meeting on research ethics. However, from the end of 2011 to the beginning of 2012, more than 20 papers by a professor at the University of Tokyo who was in charge of the educational meeting[5] were named in 2channel and accused of containing very similar images that were suspected of being fabricated. This anonymous accusation led to his resignation within a few months.[6][3] Directors of the Molecular Biology Society of Japan apologized for putting him in charge of research ethics.[7]

Shigeru Kondo of Osaka University, who served as the annual president of Molecular Biology Society of Japan in 2013, established the web site "Thinking about Science in Japan". The website contains an article alleging a history of scientific fabrication incidents in Japan,[8] and it invited people who have pointed out the paper's fraud on anonymous sites such as 2channel to write in their opinions. In late June 2013, an anonymous user that would be named as "Anonymous A" in the press began making accusations on the anonymous message board. The anonymous accusations led to a three-day symposium on research ethics issues was held at the Molecular Biology Society of Japan at the end of 2013, inviting MEXT officials, editorial staff of Nature and Japanese press.[5]

In February 2014, a case of research misconduct in the STAP cell paper published in Nature broke out.[9] For the next six months, it became major headlines in Japanese press. Yoshiki Sasai, who was one of the authors of the STAP cell paper, committed suicide in August 2014.[10] The first author, Haruko Obokata, voluntarily resigned from RIKEN in December 2014.

On December 26, 2014, the investigation into the aforementioned mass paper fraud case at the University of Tokyo was concluded, and the President of the University of Tokyo disciplined himself and reported the investigation results.[11]

Allegations

2014-2015

From the end of 2014 to the beginning of 2015, "Anonymous A" posted a thread on the aforementioned board titled "Why there should be more outrage over scientific fabrications",[8] revealing that approximately 80 medical papers published in international journals such as Nature from Japanese research institutions between 1996 and 2008 contained image data suspected of being fabricated. The post by Anonymous A was immediately spread through Japanese web sites,[12][1] and Japanese major newspapers and NHK began reporting from January 9, 2015.[1][13] The MEXT, Hirofumi Shimomura, revealed at a post-cabinet press conference on January 13, 2015 that a written anonymous accusation was also sent to them on January 6.[14]

Osaka University, where the largest number of papers, at 28, were identified, conducted a preliminary investigation of all suspected papers, except for the paper authored by the professor that committed suicide in 2006. The investigation denied suspicion in one paper, determined that seven papers were inadvertently misused, and terminated the investigation for the remaining 19 papers because "the fact of fraud could not be confirmed due to the lack of data."[15] University of Tokyo published a document stating its conclusion only that it had determined that there was no research misconduct.[16] Kyushu University's internal investigation found no admission of wrongdoing.[17]

On May 19, 2015, a question regarding "Anonymous A"'s findings was asked by Junya Ogawa, at the Japanese House of Representatives. In answering the question, MEXT Parliamentary Secretary Tomohiro Yamamoto stated that "64 papers, 17 institutions, 33 researchers" were reported not to be fraudulent and "23 papers, 10 institutions, 16 researchers" were still under investigation.[18] In October of 2016, Mitsuru Sakurai submitted a question to the Chair of the Japanese House of Councillors, pointing out that the investigation of the University of Tokyo into research misconduct was inadequate.[19] He also uncovered information that the person in charge of the investigation at the University of Tokyo was a researcher who was close to the accused.

One JBC paper published by Kanazawa University was retracted on September 4, 2015.[20] As of August 2017, fourteen papers in the journals, such as Nature,[21] have been corrected.

Subsequent allegations

In addition to the aforementioned incidents, "Anonymous A" have also made allegations pointing out suspicious image data of other papers from Japan.[22] As of August 23, 2021, a total of 114 papers have been pointed out, and the corresponding authors of the pointed out papers include three Japanese Nobel Laureates in Physiology or Medicine, one of whom was obliged to make an apologetic press conference.[23] As of August 2017, five papers from major journals that were not mentioned in the original accusations[24] have been corrected after being pointed out.

See also

References

  1. Life science papers: "Image fraud" posted online. Osaka University and University of Tokyo to confirm Mainichi Shimbun, Hiroko Saito, January 09, 2015, viewed December 6, 2016 [Japanese]
  2. Normile, Dennis (25 January 2012). "Whistleblower Uses YouTube to Assert Claims of Scientific Misconduct". Science. doi:10.1126/article.27812 (inactive 2022-03-20).{{cite journal}}: CS1 maint: DOI inactive as of March 2022 (link)
  3. Internet History of Fraud Exposed Katsuo Tanaka, Journal of the Japan Skeptics, No. 24, 4-9 (2015) [Japanese]
  4. Fuyuno, Ichiko; Cyranoski, David (2006-09-01). "Mystery surrounds lab death". Nature. 443 (7109): 253. Bibcode:2006Natur.443..253F. doi:10.1038/443253a. ISSN 1476-4687. PMID 16988672. S2CID 5300169.
  5. 八田, 浩輔 (2013-12-12). "研究不正:自浄期待は「理想論」 日本分子生物学会が防止策を議論 [Japanese]". Mainichi Shimbun.
  6. "Forty-Three University of Tokyo Papers Are Tainted, Says Japanese News Report". Science. Retrieved 2022-03-22.
  7. Urgent Forum "Considering Research Misconduct - From the Standpoint of PIs and Young Scientists" Full text record Molecular Biology Society of Japan (2012.12.11) (PDF 330KB) viewed December 6, 2016 [Japanese]
  8. 捏造問題にもっと怒りを ("Why there should be more outrage over scientific fabrications") - scienceinjapan.org (Japanese). Viewed December 6, 2016. Almost all of Anonymous A's approximately 4,000 comments were deleted by the operator in January 2017, but six comments pointing out the questionable 84 papers can be found in "Doctor G 3 のメディカル・ポプリ. Some of the other deleted comments can also be viewed in the following archive: https://archive.is/tDAqj (January 6, 2015 11:59:18 UTC); https://archive.is/UEdyv (January 15, 2015 05:51:11 UTC); https://archive.is/7fBa5 (January 18, 2015 12:59:43 UTC) [Japanese]
  9. Education, David Mcneill | The Chronicle Of Higher (2014-07-06). "Academic Scandal Shakes Japan". The New York Times. ISSN 0362-4331. Retrieved 2022-03-20.
  10. Alvarez-Buylla, Arturo (2014-09-03). "Yoshiki Sasai (1962–2014)". Nature. 513 (7516): 34. Bibcode:2014Natur.513...34A. doi:10.1038/513034a. ISSN 1476-4687. PMID 25186892. S2CID 4404562.
  11. "University of Tokyo announces involvement of 11 former professors and others in paper fraud. [Japanese]". NHK. 2014-12-26. Archived from the original on 2014-12-26. Retrieved 2022-03-24.
  12. PDF file published in post #407 of the 2channel thread "Fabricated, Fraudulent Papers, General Thread Neo 24 (捏造、不正論文 総合スレネオ 24)" (covering about 90% of the points made by Anonymous A) r3hso.pdf (8MB) published 05 Jan 2015, author unknown, viewed 8 Dec 2016
  13. Preliminary investigation by Osaka University to check for paper fraud NHK February 2, 2015 viewed December 17, 2018 [Japanese]
  14. "東大・阪大の論文に「使い回し」…文科省に告発 [Japanese]". Yomiuri Shimbun. 2015-01-13.
  15. "Osaka University: Paper scandal: 27 preliminary investigations terminated, Mainichi Newspapers [Japanese]". archive.fo. 2015-04-09. Retrieved 2022-03-20.
  16. "University of Tokyo: "There is no cheating in the paper" [Japanese]". Asahi Shimbun archive.ph. 2016-01-05. Retrieved 2022-03-24.
  17. "Kyushu University: Mistaken Images in Five Papers: "No Misconduct." Mainichi Newspapers [Japanese]". archive.fo. 2015-03-18. Retrieved 2022-03-20.
  18. 189th Session of the Diet, Special Committee on the Promotion of Science, Technology and Innovation, No. 3 House of Representatives, May 19, 2015, viewed December 6, 2016 [Japanese]
  19. 集中出版. "No. 88 "So-Called" Products of Top Companies in the Pharmaceutical Industry". SHUCHU PUBLISHING (in Japanese). Retrieved 2022-03-24.
  20. Qin, Weiping; Luo, Hong; Nomura, Takahiro; Hayashi, Naoyuki; Yamashita, Tatsuya; Murakami, Seishi (2015-09-04). "Oligomeric interaction of hepatitis C virus NS5B is critical for catalytic activity of RNA-dependent RNA polymerase". Journal of Biological Chemistry. 290 (36): 22310. doi:10.1074/jbc.A115.106880. ISSN 0021-9258. PMC 5399519. PMID 26341883.
  21. Sakahira, Hideki; Enari, Masato; Nagata, Shigekazu (2015-09-23). "Correction: Corrigendum: Cleavage of CAD inhibitor in CAD activation and DNA degradation during apoptosis". Nature. 526 (7575): 728. doi:10.1038/nature15532. ISSN 1476-4687. PMID 26416741. S2CID 4453979.
  22. 匿名A氏がこれまでにネット上で指摘した”類似画像を含む論文” 111報 日本の科学と技術 2016年9月25日 2017年8月25日閲覧 [Japanese]
  23. Landers, Peter (2014-04-28). "Japanese Nobel Winner Latest to Apologize Over Stem-Cell Research". Wall Street Journal. ISSN 0099-9660. Retrieved 2022-03-22.
  24. Zhu, Weidong; Shiojima, Ichiro; Ito, Yuzuru; Li, Zhi; Ikeda, Hiroyuki; Yoshida, Masashi; Naito, Atsuhiko T.; Nishi, Jun-Ichiro; Ueno, Hiroo; Umezawa, Akihiro; Minamino, Tohru; Nagai, Toshio; Kikuchi, Akira; Asashima, Makoto; Komuro, Issei (2014-02-12). "Correction: Corrigendum: IGFBP-4 is an inhibitor of canonical Wnt signalling required for cardiogenesis". Nature. 506 (7487): 254. doi:10.1038/nature13003. ISSN 1476-4687. S2CID 2033369.
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