2-Methoxy-6-polyprenyl-1,4-benzoquinol methylase
2-Methoxy-6-polyprenyl-1,4-benzoquinol methylase (EC 2.1.1.201, ubiE (gene)) is an enzyme with systematic name S-adenosyl-L-methionine:2-methoxy-6-all-trans-polyprenyl-1,4-benzoquinol 5-C-methyltransferase.[1][2][3][4] This enzyme catalyses the following chemical reaction
- S-adenosyl-L-methionine + 2-methoxy-6-all-trans-polyprenyl-1,4-benzoquinol S-adenosyl-L-homocysteine + 6-methoxy-3-methyl-2-all-trans-polyprenyl-1,4-benzoquinol
| 2-Methoxy-6-polyprenyl-1,4-benzoquinol methylase | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifiers | |||||||||
| EC no. | 2.1.1.201 | ||||||||
| Databases | |||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB structures | RCSB PDB PDBe PDBsum | ||||||||
| |||||||||
This enzyme is involved in ubiquinone biosynthesis.
References
- Lee PT, Hsu AY, Ha HT, Clarke CF (March 1997). "A C-methyltransferase involved in both ubiquinone and menaquinone biosynthesis: isolation and identification of the Escherichia coli ubiE gene". Journal of Bacteriology. 179 (5): 1748–54. doi:10.1128/jb.179.5.1748-1754.1997. PMC 178890. PMID 9045837.
- Young IG, McCann LM, Stroobant P, Gibson F (March 1971). "Characterization and genetic analysis of mutant strains of Escherichia coli K-12 accumulating the biquinone precursors 2-octaprenyl-6-methoxy-1,4-benzoquinone and 2-octaprenyl-3-methyl-6-methoxy-1,4-benzoquinone". Journal of Bacteriology. 105 (3): 769–78. doi:10.1128/jb.105.3.769-778.1971. PMC 248499. PMID 4323297.
- Dibrov E, Robinson KM, Lemire BD (April 1997). "The COQ5 gene encodes a yeast mitochondrial protein necessary for ubiquinone biosynthesis and the assembly of the respiratory chain". The Journal of Biological Chemistry. 272 (14): 9175–81. doi:10.1074/jbc.272.14.9175. PMID 9083048.
- Barkovich RJ, Shtanko A, Shepherd JA, Lee PT, Myles DC, Tzagoloff A, Clarke CF (April 1997). "Characterization of the COQ5 gene from Saccharomyces cerevisiae. Evidence for a C-methyltransferase in ubiquinone biosynthesis". The Journal of Biological Chemistry. 272 (14): 9182–8. doi:10.1074/jbc.272.14.9182. PMID 9083049.
External links
- 2-methoxy-6-polyprenyl-1,4-benzoquinol+methylase at the US National Library of Medicine Medical Subject Headings (MeSH)
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